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The company believes that the information contained in this announcement constitutes inside information as required by the Market Abuse Regulations (EU) No. 1. 596/2014, as amended ("March"). When this announcement is issued through the Regulatory Information Service ("RIS"), the internal information is now considered to be in the public domain.
("Igraine" or "Company")
Investor update: Excalibur Medicines reports that the ARCADIA trial is completed and the commercialization plan begins
Igraine plc holds 2% of Excalibur Medicines Ltd ("EML"), which is consistent with the terms of the joint investment agreement signed with Excalibur Healthcare Services.
Excalibur Medicines Ltd (EML) is a subsidiary of Excalibur Healthcare Services, founded by leading science entrepreneur and OBE professor Chris Evans. EML brings together scientific intellectual property, international funding and a world-leading team to advance the ARCADIA experiment. Professor Evans and the Excalibur team obtained from Mubadala in Abu Dhabi (one of the world's leading sovereign wealth funds), Excalibur itself, several high net worth individuals, Igraine plc (AQSE: KING) and the British government through UKRI/Innovate UK Investment procedures.
Excalibur Medicines Ltd ("EML") has obtained exclusive rights and patents for a drug AZD1656, which is being developed as a potential treatment for COVID-19 diabetic patients. Since there are few new therapies for COVID-19 and related virus-borne diseases (most studies are combining existing therapies), this may be very attractive to large pharmaceutical and biotech buyers.
The UK-based biomedical charity St George Street Capital and the biotechnology investment company Excalibur Medicines Ltd. are pleased to announce the completion of the clinical research report of the ARCADIA Phase ll clinical trial, which aims to evaluate a treatment that can treat people with COVID- 19 diabetic patients.
St George Street Capital and Excalibur are currently in business discussions with potential licensees and partners, and are studying options for the next phase of the development and approval process. Further analysis will be performed to determine the exact nature of the biological effects of AZD1656 in order to explain the observed clinical results.
The test data shows:
Efficacy: There is a strong trend in the mortality reduction of patients receiving AZD1656. In patients receiving other medications (including dexamethasone) as part of standard care, a strong trend of improvement in mortality in patients with AZD1656 was observed.
Safety and tolerability: AZD1656 showed good tolerability in this patient population, and no serious adverse reactions (SAR) occurred. In general, no safety issues were found in the use of AZD1656 in this patient group.
Diabetes, whether it is type 1 or type 2, has been the main single cause of comorbidities during the pandemic, and one-third of all deaths due to COVID-19 in hospitals in England are related to diabetes.
Professor John Martin of UCL, Chairman of St George Street Capital and PI of the UK Innovation Fund said: "The completion of the clinical research report is an important milestone. We are encouraged by the results of the trial. These results show that AZD1656, a simple oral tablet. , May become a new treatment for COVID-19—independent of viral mutations—initiating a new wave of treatment for clinicians to meet this global challenge."
Professor Chris Evans, Executive Chairman of Igraine and Chairman and CEO of Excalibur Healthcare Services, the parent company of Excalibur Medicines Ltd., said: “We are very pleased to play our role in arranging this trial. This report confirms that AZD1656 is here to help. Those who are still vulnerable to COVID-19."
AZD1656 has been identified by St George Street Capital as a potential treatment for diabetic patients infected with COVID-19.
The purpose of the ARCADIA clinical trial is to evaluate the safety and tolerability of the glucokinase activator AZD1656, and to determine the effect of this therapy on the clinical improvement and mortality of diabetic patients hospitalized with COVID-19. The trial also explored whether AZD1656 can benefit COVID-19 patients through its impact on immune function.
ARCADIA is a randomized, double-blind, placebo-controlled phase II clinical trial involving 153 patients. The clinical trials are arranged and organized by Excalibur Healthcare Services Chairman and CEO Professor Chris Evans through its subsidiary Excalibur Medicines Ltd. Sir Chris worked closely with Professor John Martin of St George Street, a British biomedical company, and his team on the charity, which obtained permission from AstraZeneca for the initial project and running the trial.
The directors of the company published this RIS announcement after careful and prudent inquiries, and are responsible for its content.
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